Opportunity Information: Apply for PA 24 176
The NIH Mentored Research Scientist Development Award (K01) is a career development grant meant to help early-stage or transitioning researchers build toward research independence in the biomedical, behavioral, or clinical sciences. The core idea is to provide substantial protected time and financial support for an intensive, closely supervised mentored experience lasting three to five years. During this period, the award supports a structured career development plan that typically combines mentored research, specialized training, and professional development activities so the candidate can develop the skills, publication record, and scientific direction needed to compete successfully for independent research funding later on.
A key feature of this particular opportunity is its restriction related to clinical trials. This is the "Independent Clinical Trial Not Allowed" version of the parent K01, meaning the applicant cannot propose to lead an independent clinical trial, a clinical trial feasibility study, or a separate ancillary clinical trial as the main research effort. However, the award does allow the candidate to gain clinical trial experience as part of the mentored research, as long as the clinical trial is led by the mentor or co-mentor and the K01 candidate is not the lead investigator for that trial. If someone wants to be the lead investigator of a clinical trial (including an ancillary clinical trial), NIH directs them to apply to the companion funding opportunity designed for that purpose.
Across NIH Institutes and Centers, the K01 mechanism is used a bit differently depending on the Institute's mission and workforce priorities. In general, it supports mentored development toward independence, but some NIH components may emphasize the K01 for people retraining into a new scientific area or for researchers returning after a significant hiatus due to illness or major family responsibilities. Other Institutes may use K01s to cultivate expertise in specific research fields they consider high priority. In practical terms, this means applicants need to align their research and training plan with the priorities of the NIH Institute or Center they are targeting, since the same K01 structure can be applied in different ways across NIH.
Eligibility to apply is broad at the organizational level and includes many types of U.S.-based entities such as public and private institutions of higher education, state and local governments, certain tribal governments and tribal organizations, independent school districts, special district governments, public housing authorities/Indian housing authorities, nonprofits (including 501(c)(3) and non-501(c)(3)), and for-profit organizations (excluding small businesses in the "other than small businesses" category, though small businesses are also listed as eligible in the general eligibility field). The announcement also highlights additional eligible organization types often emphasized for outreach and inclusivity, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations and certain regional organizations and U.S. territories or possessions.
At the same time, there are clear limits regarding foreign involvement. Non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply directly, and non-domestic components of U.S. organizations are not eligible to apply. That said, "foreign components" as defined by the NIH Grants Policy Statement are allowed, which generally means a U.S. applicant organization may be able to include certain defined foreign activities or collaborations when justified and structured in compliance with NIH policy, even though the applicant institution itself must be domestic.
Administratively, this opportunity is issued by the National Institutes of Health as a discretionary grant program and is identified as Funding Opportunity Number PA-24-176. It falls under a wide set of CFDA (Assistance Listing) numbers reflecting NIH participation across multiple Institutes and program areas. The posting indicates an original closing date of May 7, 2027, and does not specify an award ceiling or an expected number of awards in the provided data, which is common for NIH parent announcements where budgets and award counts depend on institute-specific allocations and the merit of applications received. Overall, the opportunity is best understood as a structured, mentored bridge to independence for researchers who need dedicated time, guidance, and a formal development plan, while specifically avoiding applications where the candidate would be the person leading a clinical trial.Apply for PA 24 176
- The National Institutes of Health in the education, environment, food and nutrition, health, income security and social services sector is offering a public funding opportunity titled "Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.172, 93.173, 93.213, 93.233, 93.242, 93.273, 93.279, 93.286, 93.307, 93.310, 93.313, 93.351, 93.361, 93.398, 93.837, 93.838, 93.839, 93.840, 93.846, 93.847, 93.855, 93.865, 93.866, 93.879.
- This funding opportunity was created on 2024-04-24.
- Applicants must submit their applications by 2027-05-07.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: NIH Mentored Research Scientist Development Award (K01) - Independent Clinical Trial Not Allowed (PA-24-176)
What is the NIH Mentored Research Scientist Development Award (K01)?
The NIH Mentored Research Scientist Development Award (K01) is a career development grant intended to help early-stage or transitioning researchers build toward research independence in the biomedical, behavioral, or clinical sciences. It supports an intensive, closely supervised mentored experience and a structured career development plan.
What is the main goal of this K01 opportunity?
The main goal is to provide substantial protected time and financial support so the candidate can develop the skills, publication record, and scientific direction needed to compete successfully for independent research funding later on.
How long does the mentored K01 period last?
The mentored experience is designed to last three to five years.
What activities are typically included in the structured career development plan?
The career development plan typically combines mentored research, specialized training, and professional development activities, all organized to support the candidate's progression toward research independence.
What does "Independent Clinical Trial Not Allowed" mean for this K01?
This version of the parent K01 does not allow the candidate to propose to lead an independent clinical trial as the main research effort. The restriction also applies to a clinical trial feasibility study or a separate ancillary clinical trial led by the candidate.
Can a K01 candidate get clinical trial experience under this opportunity?
Yes. The award allows the candidate to gain clinical trial experience as part of the mentored research, as long as the clinical trial is led by the mentor or co-mentor and the K01 candidate is not the lead investigator for that trial.
What should an applicant do if they want to be the lead investigator of a clinical trial?
If a candidate wants to be the lead investigator of a clinical trial (including an ancillary clinical trial), NIH directs them to apply to the companion funding opportunity designed for that purpose, rather than this "Independent Clinical Trial Not Allowed" K01.
Is the K01 used the same way across all NIH Institutes and Centers?
No. While the general purpose is mentored development toward independence, NIH Institutes and Centers may use the K01 differently depending on their mission and workforce priorities.
How might different NIH Institutes and Centers emphasize the K01 mechanism?
Some NIH components may emphasize the K01 for researchers retraining into a new scientific area, or for individuals returning after a significant hiatus due to illness or major family responsibilities. Other Institutes may use K01s to cultivate expertise in research fields they consider high priority.
How important is alignment with an NIH Institute or Center's priorities?
It is important. Because Institutes and Centers may apply the K01 structure in different ways, applicants should align their research and training plan with the priorities of the NIH Institute or Center they plan to target.
Who is the funding agency for this opportunity?
The funding agency is the National Institutes of Health (NIH).
What is the Funding Opportunity Number for this K01 announcement?
The Funding Opportunity Number is PA-24-176.
What type of funding program is this?
This opportunity is issued by NIH as a discretionary grant program.
What is the closing date shown for this opportunity?
The posting indicates an original closing date of May 7, 2027.
Does the provided information list an award ceiling?
No. The provided information does not specify an award ceiling, which is common for NIH parent announcements where budgets can vary by Institute and application.
Does the provided information state how many awards NIH expects to make?
No. The provided information does not specify an expected number of awards, which is also common for NIH parent announcements where award numbers depend on institute-specific allocations and the applications received.
What scientific areas does the K01 support?
This K01 supports career development toward independence in the biomedical, behavioral, or clinical sciences.
What kinds of U.S. organizations are eligible to apply?
Eligibility is broad and includes many U.S.-based entities such as public and private institutions of higher education, state and local governments, certain tribal governments and tribal organizations, independent school districts, special district governments, public housing authorities/Indian housing authorities, nonprofits (including 501(c)(3) and non-501(c)(3)), and for-profit organizations.
Are small businesses eligible to apply?
The provided information notes a nuance: for-profit organizations are listed as eligible in an "other than small businesses" category, while small businesses are also listed as eligible in the general eligibility field. Based on the information provided, both appear in the eligibility descriptions.
Are organizations such as HBCUs and Hispanic-serving institutions included in eligible applicant types?
Yes. The announcement highlights additional organization types commonly emphasized for outreach and inclusivity, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Are faith-based or community-based organizations mentioned as eligible?
Yes. The information provided indicates that faith-based or community-based organizations are among the types highlighted in the announcement.
Are U.S. territories or possessions mentioned in relation to eligibility?
Yes. The announcement references certain regional organizations and U.S. territories or possessions as part of the additional eligible organization types emphasized.
Can a foreign (non-U.S.) organization apply directly?
No. Non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply directly under this opportunity.
Can a non-domestic component of a U.S. organization apply?
No. Non-domestic components of U.S. organizations are not eligible to apply.
Are any international collaborations allowed at all?
Yes, potentially. While foreign organizations cannot apply directly, the opportunity allows "foreign components" as defined by the NIH Grants Policy Statement. This generally means a U.S. applicant organization may be able to include certain foreign activities or collaborations when justified and structured in compliance with NIH policy.
What are the CFDA (Assistance Listing) numbers for this opportunity?
The opportunity falls under a wide set of CFDA (Assistance Listing) numbers reflecting NIH participation across multiple Institutes and program areas, rather than being tied to a single Assistance Listing number in the provided information.
In plain terms, what is this opportunity best suited for?
It is best suited for researchers who need dedicated protected time, guidance, and a formal mentored development plan as a bridge to independence, while specifically avoiding applications where the candidate would be leading a clinical trial.
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| Funding Opportunity |
|---|
| Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Not Allowed) Apply for PA 24 182 Funding Number: PA 24 182 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Required) Apply for PA 24 193 Funding Number: PA 24 193 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Not Allowed) Apply for PA 24 194 Funding Number: PA 24 194 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Small Business Transition Grant for New Entrepreneurs (R43/R44 Clinical Trial Not Allowed) Apply for PAR 24 131 Funding Number: PAR 24 131 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Not Allowed) Apply for PAR 24 152 Funding Number: PAR 24 152 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $375,000 |
| PHS 2024-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed) Apply for PA 24 247 Funding Number: PA 24 247 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| PHS 2024-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed) Apply for PA 24 245 Funding Number: PA 24 245 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| PHS 2024-2 Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required) Apply for PA 24 246 Funding Number: PA 24 246 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Change of Recipient Organization (Type 7 Parent Clinical Trial Optional) Apply for PA 24 254 Funding Number: PA 24 254 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Research Software Engineer (RSE) Award (R50 Clinical Trials Not Allowed) Apply for RFA OD 24 011 Funding Number: RFA OD 24 011 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Building Sustainable Software Tools for Open Science (R03 Clinical Trial Not Allowed) Apply for RFA OD 24 010 Funding Number: RFA OD 24 010 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) Postdoctoral Career Transition Award to Promote Diversity (K99/R00 - Independent Clinical Trial Required) Apply for PAR 24 226 Funding Number: PAR 24 226 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) Postdoctoral Career Transition Award to Promote Diversity (K99/R00 Independent Clinical Trial Not Allowed) Apply for PAR 24 225 Funding Number: PAR 24 225 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Limited Competition: Knockout Mouse Phenotyping Project Database (UM1) Apply for RFA RM 15 016 Funding Number: RFA RM 15 016 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Limited Competition: Knockout Mouse Production and Phenotyping Project (UM1) Apply for RFA RM 15 017 Funding Number: RFA RM 15 017 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Administrative Supplements to Promote Diversity in Research and Development Small Businesses SBIR/STTR (Admin Supp Clinical Trial Not Allowed) Apply for PA 24 255 Funding Number: PA 24 255 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Innovation Corps (I-Corps) at NIH Program for NIH and CDC Translational Research (Admin Supp Clinical Trial NOT Allowed) Apply for PA 25 212 Funding Number: PA 25 212 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Dissemination and Implementation Research in Health (R01 Clinical Trial Optional) Apply for PAR 25 144 Funding Number: PAR 25 144 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Not Allowed) Apply for PAR 25 134 Funding Number: PAR 25 134 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $375,000 |
| NIH Research Project Grant (Parent R01 Clinical Trial Required) Apply for PA 25 305 Funding Number: PA 25 305 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
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