Opportunity Information: Apply for CDC RFA PS20 20040401SUPP23
The National Network of Sexually Transmitted Diseases Clinical Prevention Training Centers (NNPTC) Program Supplement is a CDC cooperative agreement funding opportunity (CDC RFA PS20-20040401SUPP23; CFDA 93.978) intended to strengthen the US response to the mpox outbreak by expanding training and technical assistance capacity within the existing NNPTC network. Mpox is described as a zoonotic orthopoxvirus infection historically endemic in parts of Central and West Africa, with a notable surge in cases beginning in mid-May 2022 in the United States and other countries that previously had limited mpox activity. While mpox can affect anyone through close contact, the opportunity emphasizes that the current outbreak has disproportionately affected gay, bisexual, and other men who have sex with men (MSM), largely due to transmission patterns involving sustained skin-to-skin contact, including sexual contact, and exposure to contaminated items such as shared linens. Because mpox can resemble other sexually transmitted infections (STIs) clinically (for example, conditions that cause genital lesions or proctitis) and because co-infections with STIs are common, the supplement frames mpox as closely aligned with sexual health services and, in many settings, as being managed similarly to STIs.
The supplement leverages the NNPTC network because these centers already focus on sexual and reproductive health training for clinicians and public health professionals, have established expertise in infections spread through sexual contact, frequently serve MSM-focused clinical and public health audiences, and have nationwide geographic reach through partnerships with health departments and universities. The overall goal is to use those strengths to help clinicians and clinical systems integrate mpox prevention and care into routine sexual health care, rather than treating mpox as a separate, stand-alone effort. The approach is explicitly described as syndemic, meaning it aims to address mpox in the real-world context where overlapping epidemics and co-occurring conditions (including STIs and other health inequities) interact and compound risk and burden, particularly in affected communities.
Programmatically, this is a non-competitive supplemental NOFO that funds components A, B, and C under the broader PS20-2004 NNPTC award structure, meaning it is designed to add targeted mpox-related work on top of an existing NNPTC framework. Recipients are expected to develop an implementation strategy and then deliver training and technical assistance to healthcare providers and clinical settings. The training and support are meant to cover the practical and clinical essentials needed for frontline integration: mpox epidemiology and transmission; recognition of clinical presentation and differentiation from similar STI presentations; diagnostic testing; treatment considerations (noting there is no mpox-specific treatment, but that smallpox-related countermeasures may be used because of viral relatedness); vaccination strategy and delivery, including both post-exposure prophylaxis (PEP) and pre-exposure prophylaxis (PrEP); and prevention approaches appropriate for sexual health settings.
Administratively, the opportunity is run by the US Department of Health and Human Services, Centers for Disease Control and Prevention (CDC), within NCHHSTP. It is a discretionary cooperative agreement, which typically signals substantial CDC involvement in project direction, coordination, and technical collaboration. Eligibility is listed as unrestricted, subject to any additional clarifications in the full notice. The application closing date noted is April 13, 2023 (with electronic submission due by 11:59 pm ET). The award ceiling is $800,000, with an expected eight awards. In short, the supplement funds NNPTC-led, nationwide clinician training and on-the-ground technical assistance so mpox vaccination, diagnosis, and clinical management can be built into everyday sexual health care workflows, with particular attention to the populations and clinical presentations most affected in the current outbreak.Apply for CDC RFA PS20 20040401SUPP23
- The Department of Health and Human Services, Centers for Disease Control - NCHHSTP in the health sector is offering a public funding opportunity titled "The National Network of Sexually Transmitted Diseases Clinical Prevention Training Centers (NNPTC) Program Supplement" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.978.
- This funding opportunity was created on Mar 14, 2023.
- Applicants must submit their applications by Apr 13, 2023 Electronically submitted applications must be submitted no later than 1159 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $800,000.00 in funding.
- The number of recipients for this funding is limited to 8 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Frequently Asked Questions (FAQs)
What is this funding opportunity?
This opportunity is the National Network of Sexually Transmitted Diseases Clinical Prevention Training Centers (NNPTC) Program Supplement, a CDC cooperative agreement funding opportunity (CDC RFA PS20-20040401SUPP23; CFDA 93.978). It is intended to strengthen the U.S. response to the mpox outbreak by expanding training and technical assistance capacity within the existing NNPTC network.
Which federal agency is offering the supplement?
The supplement is administered by the U.S. Department of Health and Human Services (HHS), Centers for Disease Control and Prevention (CDC), within NCHHSTP.
Is this a grant or a cooperative agreement?
It is a discretionary cooperative agreement. That structure typically indicates substantial CDC involvement in project direction, coordination, and technical collaboration.
What is the purpose of the supplement?
The purpose is to expand NNPTC training and technical assistance so clinicians and clinical systems can integrate mpox prevention and care into routine sexual health care, rather than treating mpox as a separate, stand-alone effort.
Why is the NNPTC network being used for mpox work?
The NNPTC network is leveraged because these centers already focus on sexual and reproductive health training for clinicians and public health professionals, have expertise in infections spread through sexual contact, frequently serve MSM-focused clinical and public health audiences, and have nationwide geographic reach through partnerships with health departments and universities.
How does this supplement describe mpox and the current outbreak context?
Mpox is described as a zoonotic orthopoxvirus infection historically endemic in parts of Central and West Africa, with a notable surge in cases beginning in mid-May 2022 in the United States and other countries that previously had limited mpox activity.
Who has been disproportionately affected in the current outbreak, according to the notice?
The opportunity emphasizes that the current outbreak has disproportionately affected gay, bisexual, and other men who have sex with men (MSM), largely due to transmission patterns involving sustained skin-to-skin contact, including sexual contact, and exposure to contaminated items such as shared linens.
How is mpox connected to sexual health services in this supplement?
The supplement frames mpox as closely aligned with sexual health services because mpox can resemble other sexually transmitted infections (STIs) clinically (for example, conditions that cause genital lesions or proctitis) and because co-infections with STIs are common. In many settings, mpox is described as being managed similarly to STIs.
What does the supplement mean by a "syndemic" approach?
The approach is explicitly described as syndemic, meaning it aims to address mpox in the real-world context where overlapping epidemics and co-occurring conditions (including STIs and other health inequities) interact and compound risk and burden, particularly in affected communities.
Is this a competitive funding opportunity?
No. It is described as a non-competitive supplemental NOFO that adds targeted mpox-related work on top of an existing NNPTC framework.
What parts of the broader NNPTC award structure does this supplement fund?
The supplement funds components A, B, and C under the broader PS20-2004 NNPTC award structure.
What are recipients expected to do with the funds?
Recipients are expected to develop an implementation strategy and then deliver training and technical assistance to healthcare providers and clinical settings to support integration of mpox prevention and care into routine sexual health care workflows.
What topics should the training and technical assistance cover?
The supplement indicates training and support are meant to cover practical and clinical essentials needed for frontline integration, including: mpox epidemiology and transmission; recognition of clinical presentation and differentiation from similar STI presentations; diagnostic testing; treatment considerations; vaccination strategy and delivery; and prevention approaches appropriate for sexual health settings.
What does the supplement say about recognizing mpox in clinical settings?
It highlights the need for training on recognizing mpox clinical presentation and differentiating it from similar STI presentations, including conditions that cause genital lesions or proctitis.
What does the supplement include regarding mpox diagnostic testing?
Diagnostic testing is explicitly listed as a training and technical assistance topic to support frontline clinical integration.
Does the supplement describe mpox treatment?
It notes there is no mpox-specific treatment, but that smallpox-related countermeasures may be used because of viral relatedness. Treatment considerations are included among the training topics.
What does the supplement say about mpox vaccination?
Vaccination strategy and delivery are included as core topics, including both post-exposure prophylaxis (PEP) and pre-exposure prophylaxis (PrEP).
What types of prevention approaches are expected to be addressed?
The supplement calls for prevention approaches appropriate for sexual health settings, as part of integrating mpox services into routine sexual health care.
Who is the intended audience for the training and technical assistance?
The intended audience is healthcare providers and clinical settings, with training and technical assistance delivered through the NNPTC network. The notice also references NNPTC strengths in serving clinician and public health professional audiences, including MSM-focused clinical and public health audiences.
What is the overall integration goal for clinical workflows?
The stated goal is to build mpox vaccination, diagnosis, and clinical management into everyday sexual health care workflows, rather than operating mpox response as a separate effort.
What is the CFDA number associated with this opportunity?
The CFDA number listed is 93.978.
What is the application deadline?
The closing date noted is April 13, 2023, with electronic submission due by 11:59 pm ET.
What is the maximum award amount?
The award ceiling is $800,000.
How many awards are expected?
The opportunity states an expected eight awards.
Who is eligible to apply?
Eligibility is listed as unrestricted, subject to any additional clarifications in the full notice.
What makes this opportunity a "supplement" rather than a stand-alone program?
It is described as a non-competitive supplement that adds targeted mpox-related work on top of the existing PS20-2004 NNPTC award structure, expanding training and technical assistance capacity within the established NNPTC network.
What key transmission details does the notice emphasize?
The notice states that while mpox can affect anyone through close contact, the current outbreak has been shaped by transmission patterns involving sustained skin-to-skin contact (including sexual contact) and exposure to contaminated items such as shared linens.
Why does the supplement emphasize STI co-infection and overlapping symptoms?
Because mpox can resemble other STIs clinically (including genital lesions or proctitis) and co-infections with STIs are common, the supplement positions mpox integration within sexual health services as a practical clinical and public health approach.
What is the main national public health outcome this supplement is trying to support?
Based on the description provided, the main intended outcome is a stronger U.S. response to the mpox outbreak through expanded nationwide clinician training and on-the-ground technical assistance, enabling routine sexual health systems to deliver mpox vaccination, diagnosis, and clinical management.
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