Interventions to Address Disparities in Liver Diseases and Liver Cancer (R01 - Clinical Trials Optional) | PAR 25 299

Opportunity Information: Apply for PAR 25 299

The National Institutes of Health (NIH) is offering the grant opportunity "Interventions to Address Disparities in Liver Diseases and Liver Cancer (R01 - Clinical Trials Optional)" under Funding Opportunity Number PAR-25-299. It is an NIH R01 discretionary grant designed to support intervention research aimed at reducing inequities in liver diseases and liver cancer outcomes among U.S. populations that experience health disparities. The emphasis is on interventions that work across multiple levels and/or multiple domains, meaning applicants are encouraged to design strategies that do not focus on only one point of influence (such as the individual patient) but instead address a combination of factors such as patients, families, clinicians, healthcare systems, communities, and policies, or multiple interacting drivers like access, quality of care, social determinants, and structural barriers. Clinical trials are allowed but not required, so projects can range from non-trial intervention studies through pragmatic or community-based trials when appropriate.

A key feature of this reissued Notice of Funding Opportunity (NOFO) is that it aligns with NIH's simplified peer review criteria that apply to application due dates after January 25, 2025. In practical terms, this signals that proposals will be evaluated using updated review standards intended to make scoring clearer and more consistent, and applicants should be careful to track the current NIH review framework and align the application narrative, significance, innovation, and approach accordingly.

Eligibility is broad and includes many types of U.S.-based organizations and governments. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations other than federally recognized tribal governments; public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (as long as they are not institutions of higher education in that specific category); for-profit organizations other than small businesses; and small businesses. The NOFO also explicitly highlights additional eligible applicant types, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions. This wide eligibility is consistent with the topic, since meaningful disparity-reduction work often depends on partnerships among academic centers, healthcare systems, community organizations, and local or tribal governments.

At the same time, there are clear limits on foreign involvement. Non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply, and non-domestic components of U.S. organizations are also not eligible to apply. However, "foreign components" are allowed as defined in the NIH Grants Policy Statement, which typically means that certain parts of the research may be conducted outside the U.S. or involve international collaborators when justified, properly documented, and compliant with NIH policy, even though the applicant organization itself must be eligible and U.S.-based.

From a funding classification standpoint, the opportunity is listed under CFDA numbers 93.273, 93.307, and 93.399, and it sits within the Education and Health activity category. The listing shows an original closing date of January 7, 2028, indicating a multi-year window during which NIH expects to accept applications on relevant due dates associated with this NOFO. The award ceiling and expected number of awards are not specified in the provided source data, which is common for NIH mechanisms where budgets are proposal-driven and awards depend on annual appropriations, scientific merit, program priorities, and available funds.

Overall, PAR-25-299 is best understood as an NIH R01 call for rigorous, intervention-focused research that can measurably reduce liver disease and liver cancer disparities in the U.S., with an explicit preference for multi-level or multi-domain approaches and an applicant pool that includes not only universities and health systems but also community, tribal, and other organizations positioned to implement and evaluate solutions in real-world settings.

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Interventions to Address Disparities in Liver Diseases and Liver Cancer (R01 - Clinical Trials Optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273, 93.307, 93.399.
• This funding opportunity was created on 2024-12-05.
• Applicants must submit their applications by 2028-01-07.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 25 299

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