Opportunity Information: Apply for RFA MH 18 251
This funding opportunity is a limited competition NIH cooperative agreement (U24) to support the continued operation of the Data Coordinating Center (DCC) for the National NeuroAIDS Tissue Consortium (NNTC). The NNTC is a national shared resource designed to make high-value clinical data and biological specimens available to NeuroAIDS researchers. The overarching scientific purpose is to accelerate research aimed at understanding how HIV-1 affects the central nervous system (CNS) and peripheral nervous system (PNS), especially in the modern era of antiretroviral therapy (ART), and to support studies that move the field toward eliminating or curing HIV-1 infection in the CNS. Only one award is expected, reflecting the limited-competition nature of the announcement, and it is specifically intended to continue the DCC activities previously supported under an earlier solicitation (RFA-MH-13-071).
The DCC sits at the center of the consortium and is responsible for the infrastructure that allows multiple NNTC clinical sites to operate as a coordinated national program. Its first major role is operational and informatics-focused: providing management, database development and maintenance, and related capabilities that keep clinical workflows and brain banking operations running effectively across sites. In practical terms, the DCC serves as the NNTC data repository and the hub for organizing, standardizing, and safeguarding the consortiums datasets so that information collected at different sites can be combined and used reliably for analyses and resource sharing.
A second core function is to provide scientific expertise in biostatistics and HIV-1 epidemiology. This is not just basic data storage; the DCC is expected to enable broad, high-quality analyses of the NNTC clinical database and to support the consortium in meeting performance goals. That includes helping affiliated clinical sites evaluate recruitment and retention targets using sound statistical approaches, monitoring cohort composition and follow-up, and ensuring that the data being generated can support robust, publishable research that answers meaningful questions about HIV-related neurologic disease and persistence.
A third highlighted objective is expansion of coordination beyond the immediate NNTC sites. The announcement emphasizes building the capability to coordinate distribution of data and specimens that may be stored at other national and international clinical sites. The intent is to widen access to CNS and PNS resources that are particularly difficult to obtain, including specimens from HIV-1 infected individuals across the lifespan. This part of the scope reflects a practical challenge in NeuroAIDS research: well-characterized neurologic tissues and linked clinical data are scarce, and coordinated distribution can reduce duplication, increase sample utility, and broaden the types of questions researchers can realistically pursue.
In the division of responsibilities, the clinical sites affiliated with the NNTC retain direct patient-facing duties. They handle all participant contact and conduct ante mortem clinical assessments. They are also responsible for collecting and housing post mortem clinical specimens. The DCC, in contrast, aggregates and curates the resulting information and makes it usable as a coherent resource. The repository functions include managing clinical assessment data as well as post mortem-derived data such as brain pathology reports, laboratory test results from collected specimens and fluids, and a comprehensive inventory of specimens held at each clinical site. The scope also explicitly includes research-generated data products, for example bioinformatics datasets, which signals that the DCC is expected to support modern data types and not only traditional clinical and pathology records.
Administratively, the opportunity is offered by the U.S. Department of Health and Human Services through the National Institutes of Health, using the cooperative agreement mechanism, which typically implies substantial NIH programmatic involvement and coordination with the awardee. The activity category is health, and the CFDA numbers listed are 93.242 and 93.855. Eligible applicants are public and state-controlled institutions of higher education. The expected number of awards is one, with an award ceiling of $600,000. The opportunity was created on April 19, 2017, with an original closing date of July 26, 2017. The announcement also notes a related companion FOA (RFA-MH-18-250) connected to the broader NNTC effort, underscoring that this DCC award is one component of a larger, coordinated consortium structure.Apply for RFA MH 18 251
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition: National NeuroAIDS Tissue Consortium (NNTC) Data Coordinating Center (U24)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242, 93.855.
- This funding opportunity was created on Apr 19, 2017.
- Applicants must submit their applications by Jul 26, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $600,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Public and State controlled institutions of higher education.
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